PRF is a blood fraction rich in concentrated growth factors and other useful elements. They are obtained by centrifuging blood taken from a patient without the addition of any chemical substances, which means that what is taken from the body is returned to the body. During periodontal and oral surgical interventions, PRF is mixed with artificial bone and, thanks to the mentioned characteristics it improves bone regeneration. PRF protects the wound after tooth extraction. It also affects the function of stem cells and thus contributes to better regeneration of bone and soft tissues. PRF can be mixed with artificial bone, can be applied on its own, or can be applied in the form of membranes. At the site of application, it enhances the formation of new blood vessels, the supply of oxygen and nutrients, which contributes to better tissue regeneration and wound healing.